Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Hear Res. 2015 May 15;327:102–108. doi: 10.1016/j.heares.2015.04.016

Figure 2.

Figure 2

A schematic representation of transcriptional activator-like effector nucleases (TALENs). TALENs are composed of TALE repeats and FokI nuclease. TALENs work in paris, binding two complementary DNA strands across a spacer over which FokI nuclease dimerizes to create a double-stranded break. Each TALE repeat can recognize one single nucleotide, and multiple TALE repeats are joined in tandem to target a specific DNA sequence.