Table 1.
Cardiac function analysed by echocardiography
| Parameters | WT | TRPC1/C4-DKO | WT |
TRPC1/C4-DKO |
P-value TAC vs. TAC | ||
|---|---|---|---|---|---|---|---|
| Basal (n = 12) | Basal (n = 12) | Sham (n = 4) | TAC (n = 8) | Sham (n = 4) | TAC (n = 7) | ||
| Body weight (g) | 30.8 ± 1.5 | 30.4 ± 2.8 | 28.5 ± 5.2 | 31.6 ± 1.8 | 31.2 ± 0.96 | 31.1 ± 2.8 | |
| P-value | 0.683 | 0.146 | 0.935 | 0.690 | |||
| HR (BPM) | 425 ± 32 | 382 ± 34 | 400 ± 36 | 481 ± 35 | 368 ± 32 | 507 ± 53 | |
| P-value | 0.015 | 0.004 | 0.0012 | 0.280 | |||
| LV volume diastole (µL) | 96.1 ± 9.9 | 88.7 ± 9.9 | 101.3 ± 6.7 | 112.9 ± 18 | 95.0 ± 7.9 | 89.8 ± 13.1 | |
| P-value | 0.161 | 0.326 | 0.491 | 0.016 | |||
| LV volume systole (µL) | 55.1 ± 11.3 | 47.9 ± 7.4 | 53.1 ± 4.1 | 77.7 ± 21 | 54.8 ± 5.6 | 55.2 ± 13.1 | |
| P-value | 0.095 | 0.089 | 0.961 | 0.030 | |||
| EF (%) | 43.0 ± 5.5 | 46.2 ± 3.4 | 45.4 ± 4.0 | 30.6 ± 7.0 | 42.3 ± 2.0 | 39.8 ± 6.2 | |
| P-value | 0.303 | 0.008 | 0.468 | 0.019 | |||
| MVE-wave (mm/s) | 993 ± 142 | 930 ± 157 | 859 ± 35 | 1099 ± 142 | 913 ± 99 | 1283 ± 227 | |
| P-value | 0.330 | 0.021 | 0.014 | 0.078 | |||
| MVA-wave (mm/s) | 643 ± 49 | 620 ± 137 | 577 ± 46 | 448 ± 296 | 542 ± 62 | 333 ± 244 | |
| P-value | 0.593 | 0.498 | 0.149 | 0.596 | |||
| IVRT (ms) | 15.0 ± 2.2 | 16.0 ± 2.1 | 14.7 ± 2.3 | 11.1 ± 1.9 | 16.2 ± 1.6 | 9.9 ± 2.9 | |
| P-value | 0.318 | 0.014 | 0.003 | 0.358 | |||
| MV E/A | 1.55 ± 0.28 | 1.52 ± 0.18 | 1.46 ± 0.15 | 3.58 ± 3.9 | 1.69 ± 0.23 | 5.75 ± 3.7 | |
| P-value | 0.739 | 0.329 | 0.073 | 0.457 | |||
LV, left ventricle; EF, ejection fraction; IVRT, isovolumetric relaxation time; MVE, mitral valve early wave peak; MVA, mitral valve atrial wave peak.