Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Bioorg Med Chem. 2015 Jul 14;23(17):5789–5798. doi: 10.1016/j.bmc.2015.07.006

Table 5.

Antifungal activity and cytotoxicity of the head-to-tail bisindole analogs with varied core structures

# Structure MIC (μg/ml)†
graphic file with name nihms710320u4.jpg C. alb C. kru C. gla C. par C. neo CC50 (μg/ml)
P32 graphic file with name nihms710320t32.jpg 0.5 0.5 0.13 0.5 2 34.6
P33 graphic file with name nihms710320t33.jpg 0.79 1 0.13 0.31 0.5 13.4
P34 graphic file with name nihms710320t34.jpg 0.25 0.5 0.06 0.13 0.13 1.5
P35 graphic file with name nihms710320t35.jpg 16 16 32 8 1 20.7
P36 graphic file with name nihms710320t36.jpg 8 8 1.59 2.52 3.94 32.5
P37 graphic file with name nihms710320t37.jpg 2 8 0.31 2 2 25.5
P38 graphic file with name nihms710320t38.jpg 4 8 1 0.79 1 20.7
P39 graphic file with name nihms710320t39.jpg 4 25.4 2.52 2 1 40.5
P40 graphic file with name nihms710320t40.jpg 3.17 16 5.04 2 4 27.5
P41 graphic file with name nihms710320t41.jpg 0.31 4 0.13 0.5 0.5 17.1
P42 graphic file with name nihms710320t42.jpg 0.4 4 1 0.5 1 50.5
P43 graphic file with name nihms710320t43.jpg 1 1.26 0.16 1 6.25 91.9
†

MICs are the geometric mean of three independent assays, MIC values < 1 μg/ml are in blue.

Fungal strains: C. alb, Candida albicans (WTBF-50); C. kru, Candida krusei (WTBF-51); C. gla, Candida glabrata (WTBF-86); C. par, Candida parapsilosis (WTBF-88); C. neo, Cryptococcus neoformans Cn18 (WTBF-106).