Table 2.
Differences in serum iron and serum ferritin between PD Cases and Controls, stratified by gender, ethnicity, and Hp phenotype.
| iPD Cases | Controls | p-value | age-adjusted p-value |
||||
|---|---|---|---|---|---|---|---|
| Serum iron ug/100 ml |
Total | n. | Mean (SD) | n. | Mean (SD) | ||
| Total | 354 | 128 | 83.28 (29.46) | 226 | 94.00 (34.14) | 0.003 | 0.006 |
| Women | 162 | 40 | 79.28 (30.45) | 122 | 88.23 (29.61) | 0.102 | 0.103 |
| Men | 192 | 88 | 85.10 (28.52 | 104 | 100.77 (37.82) | 0.002 | 0.004 |
| Ethnicity | |||||||
| Non-hispanic White | 314 | 121 | 84.05 (28.77) | 198 | 93.72 (31.38) | 0.007 | 0.006 |
| African American | 12 | 1 | 59.00 | 11 | 82.36 (27.41) | 0.434 | 0.394 |
| Hispanic | 4 | 3 | 54.33 (20.21) | 1 | 154.00 | 0.051 | 0.346 |
| Asian | 8 | 4 | 102.25 (23.48) | 4 | 90.50 (7.76) | 0.379 | 0.785 |
| Native American | 1 | 1 | 60.00 | 0 | - | - | - |
| Multiethnic | 15 | 3 | 73.00 (59.75) | 12 | 105.42 (69.98) | 0.477 | 0.734 |
| Hp phenotype | |||||||
| Hp 1-1 | 51 | 16 | 91.75 (37.42) | 35 | 94.66 (32.47) | 0.779 | 0.719 |
| Hp 2-1 | 164 | 62 | 79.13 (29.41) | 102 | 94.51 (39.11) | 0.008 | 0.015 |
| Hp 2-2 | 130 | 46 | 84.54 (26.10) | 84 | 91.60 (27.07) | 0.153 | 0.211 |
| Women | |||||||
| Hp 1-1 | 19 | 4 | 79.50 (43.47) | 15 | 96.13 (30.65) | 0.387 | 0.426 |
| Hp 2-1 | 80 | 23 | 78.96 (33.03) | 57 | 83.94 (31.00) | 0.525 | 0.596 |
| Hp 2-2 | 60 | 13 | 79.77 (25.07) | 47 | 90.09 (26.50) | 0.214 | 0.150 |
| Men | |||||||
| Hp 1-1 | 32 | 12 | 95.83 (36.35) | 20 | 93.55 (34.50) | 0.860 | 0.950 |
| Hp 2-1 | 84 | 39 | 79.23 (27.52) | 45 | 107.91 (44.26) | 0.001 | 0.002 |
| Hp 2-2 | 70 | 33 | 86.42 (26.63) | 37 | 93.51 (28.02) | 0.283 | 0.450 |
| Serum ferritin ng/ml | |||||||
| Total | 206 | 36 | 128.03 (172.29) | 170 | 101.46 (99.24) | 0.210 | 0.154 |
| Women | 115 | 11 | 45.09 (32.74) | 104 | 77.45 (59.22) | 0.078 | 0.125 |
| Men | 91 | 25 | 164.52 (195.72) | 66 | 139.29 (132.93) | 0.483 | 0.371 |
| Ethnicity* | |||||||
| Non-hispanic White | 176 | 34 | 133.94 (175.59) | 142 | 88.95 (66.11) | 0.016 | 0.014 |
| All other Ethnicities | 30 | 2 | 27.50 (9.19) | 28 | 164.88 (183.90) | 0.308 | 0.276 |
| Hp phenotype | |||||||
| Hp 1-1 | 30 | 4 | 160.25 (207.65) | 26 | 87.31 (56.78) | 0.128 | 0.181 |
| Hp 2-1 | 95 | 17 | 157.17 (218.75) | 78 | 114.51 (118.11) | 0.260 | 0.139 |
| Hp 2-2 | 77 | 15 | 86.40 (84.28) | 62 | 93.58 (88.60) | 0.777 | 0.705 |
| Women | |||||||
| Hp 1-1 | 14 | 1 | 120 | 13 | 70.92 (38.53) | 0.243 | 0.124 |
| Hp 2-1 | 54 | 7 | 36.42 (23.04) | 47 | 79.42 (64.81) | 0.090 | 0.116 |
| Hp 2-2 | 44 | 3 | 40.33 (25.77) | 41 | 79.21 (60.56) | 0.280 | 0.385 |
| Men | |||||||
| Hp 1-1 | 16 | 3 | 173.66 (252.19) | 13 | 103.69 (68.19) | 0.356 | 0.381 |
| Hp 2-1 | 41 | 10 | 241.70 (255.80) | 31 | 167.70 (156.56) | 0.276 | 0.109 |
| Hp 2-2 | 33 | 12 | 97.91 (90.53) | 21 | 121.61 (123.92) | 0.567 | 0.411 |
*
Because numbers were too small for separate analyses of ferritin by all different ethnicities, the study population was split in two ethnic groups: Non-hispanic Whites, and All other Ethnicities.