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. 2015 Sep 1;9:332. doi: 10.3389/fncel.2015.00332

Figure 6.

Figure 6

Relative fold change values of selected dysregulated genes related to death, stress and mitochondrion by qPCR in enriched sciatic nerve-derived Schwann cell samples of 60-day-old SOD1G93A (TG) mice compared to the age matched wild-type (WT) mice. Schwann cells were enriched by means of flow cytometry cell sorting technique from the sciatic nerves of the mice. Significant increases in expression are seen in genes related to Death (Ngfr, Cdkn1b, E2f1, Traf2, and Erbb3; A). Up-regulated H2afx is related to Stress category (B). Down-regulated Cdkn1a and Foxo3 are related to Death and Stress categories respectively (B). Up-regulated Hspa1 and Prdx belonged to Death, Stress and Mitochondrion categories (B). Up-regulated Mapk10 (Stress and Mitochondrion categories) and down-regulated Mtor (Mitochondrion) were also shown down-regulated (B). A pool of the non-ALS group was used as reference samples with a reference value of 1, see text for details. Means ± SEM; n = 6 for each group; * and **p-values indicates the < 0.05 and < 0.01 levels of significance, respectively, according to unpaired two-tailed t-test.