Table 4.
KEGG pathways obtained from gene lists related to Death, Stress and Mitochondrion from 60-day-old SOD1G93A sciatic nerve microarray analyses.
| Term | Pathways | Number of genes | Categories/Genes | ||
|---|---|---|---|---|---|
| Death | Stress | Mitochondrion | |||
| mmu00280 | Valine, leucine and isoleucine degradation | 12 | Abat, Acaa2, Acad8, Acadsb, Acat1, Aldh6a1, Aldh9a1, Bcat2, Bckdha, Ehhadh, Hmgcs2, Oxct1 | ||
| mmu00640 | Propanoate metabolism | 8 | Abat, Acaca, Acacb, Acat1, Aldh6a1, Aldh9a1, Ehhadh, Suclg2 | ||
| mmu00650 | Butanoate metabolism | 7 | Abat, Acat1, Acsm3, Aldh9a1, Ehhadh, Hmgcs2, Oxct1 | ||
| mmu00071 | Fatty acid metabolism | 7 | Acaa2, Acadsb, Acat1, Adh1, Aldh9a1, Cpt1a, Ehhadh | ||
| mmu04110 | Cell cycle | 7 | Cdkn1a, Cdkn1b, E2f1, Skp2, Tgfb2 | Gadd45a, Pttg1, Cdkn1a | |
| mmu04012 | ErbB signaling pathway | 6 | Cdkn1a, Cdkn1b, Erbb3, Pak7 | Mapk10, Cdkn1a | Pak7, Mapk10, Mtor |
| mmu00020 | Citrate cycle (TCA cycle) | 5 | Aco1, Acly, Idh1, Idh3a, Suclg2 | ||
| mmu00380 | Tryptophan metabolism | 5 | Cat | Acat1, Aldh9a1, Cat, Ehhadh, Maob | |
| mmu00480 | Glutathione metabolism | 5 | Gclc, Rrm2b | Gclc, Rrm2b | Gstz1, Idh1, Mgst1, Rrm2b |
| mmu00330 | Arginine and proline metabolism | 5 | Aldh18a1, Aldh9a1, Ass1, Glud1, Maob | ||
| mmu04622 | RIG-I-like receptor signaling pathway | 5 | Traf2, Traf3 | Mapk10 | Mapk10, Mapk12, Nlrx1 |
| mmu00982 | Drug metabolism | 5 | Adh1, Gstz1, Maob, Mgst1, Ugt1a10 | ||
| mmu00310 | Lysine degradation | 4 | Acat1, Aldh9a1, Bbox1, Ehhadh | ||
| mmu00620 | Pyruvate metabolism | 4 | Acaca, Acacb, Acat1, Aldh9a1 | ||
| mmu00600 | Sphingolipid metabolism | 4 | Sphk1, Sphk2 | Asah2, Cerk | |
| mmu00072 | Synthesis and degradation of ketone bodies | 3 | Acat1, Hmgcs2, Oxct1 | ||
KEGG pathways were obtained from gene lists related to Death, Stress and Mitochondrion from 60-day-old SOD1G93A sciatic nerve microarray analyses and genes included in these pathways and categories are shown in the table. EASE score was set to 0.05.