Figure 1.

Effect of reactive oxygen species scavengers on fatigue. (A) Effect of pretreatment with ROS scavenger, N-acetylcysteine (circles) vs. control (squares) on the fatigue profile of the tibialis anterior muscle in humans stimulated at 10 Hz with a surface electrode. The drop in force was significant under both conditions but the force was greater with N-acetylcysteine treatment. Reprinted from Reid et al. (1994) with rights and permission from American Society for Clinical Investigation. (B) Effect of the N-acetylcysteine on the development of diaphragm fatigue in an anesthetized intact rabbit preparation. Reprinted from Shindoh et al. (1990) with permission. (C) Effect of N-acetylcysteine on the development of fatigue in isolated mouse extensor digitorum longus muscle. Reprinted from Katz et al. (2014) with permission. ^*, ^** and ^*** indicate significantly different from corresponding control value (open circles) at p < 0.05, p < 0.01, and p < 0.001 respectively.