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. 2015 Sep 1;9:341. doi: 10.3389/fncel.2015.00341

Figure 1.

Figure 1

Paradigm of severe mitochondrial alterations in ALS motor neurons. The first (A–C) and the second column (D–F) show at low and high magnification, respectively, the severe damage produced to mitochondria by the SOD1 G93A ALS-inducing mutation. On the right column (G–I), the beneficial effects of autophagy, induced by lithium, are evident. Scale bars: A–C = 0.12 μm; D = 0.55 μm; E = 0.15 μm; F = 0.13 μm; G–I = 0.12 μm; from Fornai et al. (2008a), Supporting Information, SI Figure 21; Copyright (2008) National Academy of Sciences, USA.