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Effects of RBP on serum insulin levels (A) and HOMAR-IR values (B) in HCHF-fed rats. Oral administration of RBP 100 or 500 mg/kg or pioglitazone 10 mg/kg daily for 6 weeks significantly decreased serum insulin and HOMA-IR. (*: p < 0.05, significant increase as compared to normal controls; #: p < 0.05, significant decrease as compared to HCHF-control group, n = 7/group).
