Table 5.

Effects of gene-gene interactions on folate deficiency.

Genotype 1	Genotype 2	NL/NH 1	OR (95%Cl)		p 2	Trend test	p 2
MTHFR C677T	MTHFR A1298C
CC + CT	AC + CC	33/109	Reference			0.16 (0.02)	<0.001
CC + CT	AA	50/160	1.09 (0.65–1.82)		0.757
TT	AC + CC	0/0	-		-
TT	AA	48/68	2.45 (1.41–4.28)		0.002
MTHFR C677T	MTR A2756G
CC + CT	AA	65/225	Reference			0.19 (0.02)	<0.001
CC + CT	AG + GG	18/44	1.69 (0.88–3.23)		0.116
TT	AA	35/57	2.22 (1.32–3.74)		0.003
TT	AG + GG	13/11	4.13 (1.68–10.13)		0.002
MTHFR C677T	MTRR A66G
CC + CT	AA	29/91	Reference			0.15 (0.02)	0.001
CC + CT	AG + GG	54/178	1.02 (0.60–1.73)		0.954
TT	AA	12/21	2.03 (0.84–4.87)		0.114
TT	AG + GG	36/47	2.50 (1.33–4.67)		0.004
MTHFR A1298C	MTR A2756G
AC + CC	AA	26/92	Reference			0.11 (0.02)	0.019
AC + CC	AG + GG	7/17	2.07 (0.72–5.92)		0.177
AA	AA	74/190	1.50 (0.89–2.54)		0.131
AA	AG + GG	24/38	2.54 (1.26–5.15)		0.010
MTHFR A1298C	MTRR A66G
AC + CC	AA	13/38	Reference			0.08 (0.02)	0.088
AC + CC	AG + GG	20/71	0.87 (0.38–1.99)		0.743
AA	AA	28/74	1.18 (0.54–2.60)		0.680
AA	AG + GG	70/154	1.46 (0.72–2.98)		0.297
MTR A2756G	MTRR A66G
AA	AA	30/93	Reference			0.10 (0.02)	0.032
AA	AG + GG	70/189	1.16 (0.69–1.94)		0.570
AG + GG	AA	11/19	1.73 (0.70–4.29)		0.240
AG + GG	AG + GG	20/36	2.09 (1.01–4.29)		0.046

¹ N_L: number of low folate patients (<10 nmol/L); N_H: number of high folate patients (≥10 nmol/L); ² Adjusted for sex, age, clinical center, height, and weight.