Table 7.
Cumulative effects of risk genotypes 1 on folate deficiency.
| Number of risk genotypes | Low folate 2 | High folate 2 | OR (95%Cl) | p 3 | p trend 3 |
|---|---|---|---|---|---|
| 0 | 10 (7.6) | 33 (9.8) | Reference | 0.001 | |
| 1 | 32 (24.4) | 106 (31.5) | 1.01 (0.44–2.32) | 0.989 | |
| 2 | 40 (30.5) | 132 (39.2) | 1.17 (0.52–2.63) | 0.710 | |
| 3 | 41 (31.3) | 58 (17.2) | 2.53 (1.10–5.85) | 0.029 | |
| 4 | 8 (6.1) | 8 (2.4) | 3.77 (1.07–13.27) | 0.039 | |
| ≥3 | 49 (37.4) | 66 (19.6) | 2.68 (1.18–6.09) | 0.019 |
1 Risk genotypes were defined as MTHFR 677TT, MTHFR 1298AA, MTR 2756AG + GG, and MTRR 66AG + GG. 2 Data are presented as the number of cases (percentage). Low folate: serum folate level <10 nmol/L; high folate: serum folate level ≥10 nmol/L. 3 Adjusted for sex, age, clinical center, height, and weight.