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. 2015 Sep 1;5:13699. doi: 10.1038/srep13699

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Copyright © 2015, Macmillan Publishers Limited

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(A) The effect of Q4c on LPS-stimulated NO release from primary peritoneal macrophages. Nitrite levels were assessed by Griess reagent. Data are shown as mean ± SEM (n = 5). Significant difference between LPS and test groups are indicated, **p < 0.01; ***p < 0.001.(B) The effect of iNOS antagonist SMT on the in vivo anti-inflammatory activity of Q4c. Data are shown as mean ± SEM (n = 7). Significant difference from vehicle, *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001. Significant difference between Q4c treatments in the absence and presence of SMT, #p < 0.05. Statistical analysis was performed by two-way ANOVA, followed by Tukey’s post-tests.