Table 2.
Examination of the relationship between the acneiform rash and CA simple sequence repeat in intron 1 (CA-SSR1) polymorphism of the epidermal growth factor receptor (EGFR) gene
| Criterion | Subgroup [n (%)] | Test | Test value | p value | ||||
|---|---|---|---|---|---|---|---|---|
| SS | SL | LL | Short n(CA) ≤ 35 | Long n(CA) > 35 | ||||
| Grouped NCI CTCAE v3.0 scale vs. sum of CA repetitions of a single allele [cutoff S ≤ 17(CA), L > 17(CA)] | Chi-squared Pearson’s test |
χ 2 = 8.09 df = 2 |
p = 0.059 | |||||
| Grade 0–1 | 2 (3) | 11 (18) | 3 (5) | |||||
| Grade 2–3 | 18 (30) | 16 (27) | 10 (17) | |||||
| Grouped NCI CTCAE v3.0 scale vs. sum of CA repetitions of two alleles [cutoff n(CA) ≤ 35, n(CA) > 35] | Chi-squared Pearson’s (Yeats’) test |
χ 2 = 0.85 df = 1 |
p = 0.356 | |||||
| Grade 0–1 | 7 (12) | 9 (15) | ||||||
| Grade 2–3 | 27 (45) | 17 (28) | ||||||
| Body surface area covered by the rash (%) vs. sum of CA repetitions of a single allele [cutoff S ≤ 17(CA), L > 17(CA)] | 20 (33) | 27 (45) | 13 (22) | Kruskal–Wallis test | H = 4.781 | p = 0.092 | ||
| Spearman’s rank correlation |
R = −0.258 t = −2.035 |
p = 0.046 | ||||||
| Body surface area covered by the rash (%) vs. sum of CA repetitions of two alleles and the cutoff n(CA) ≤ 35, n(CA) > 35 | 34 (57) | 26 (43) | Mann–Whitney U test | Z = 2.039 | p = 0.042 | |||
| Spearman’s rank correlation |
R = −0.266 t = −2.105 |
p = 0.040 | ||||||
| Body surface area covered by the rash (%) vs. sum of CA repetitions of two alleles | The whole group of patients | Pearson’s correlation (Fig. 2) |
r = −0.3251 r 2 = 0.106 |
p = 0.011 | ||||
χ 2 chi-squared, df degrees of freedom, L long allele, NCI CTCAE National Cancer Institute Common Toxicity Criteria for Adverse Events, S short allele