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Induction and recovery of pazopanib-resistance. (a) induction: sensitivity to pazopanib after 1, 2 or 4 weeks of culturing the parental cells (PAR) in the presence of the drug, compared to the pazopanib-resistant cell line (PAZ; cultured for 3–4 months). (b) recovery: sensitivity to pazopanib 1, 2 or 4 weeks after drug withdrawal from the pazopanib-resistant cells (PAZ; cultured for 3–4 months), compared to the parental cells (PAR). Results are shown as mean ± SEM
