Table 2.
Induction of resistance to sorafenib, pazopanib or erlotinib
| IC50 value (μM) | Resistance factor | |||
|---|---|---|---|---|
| Drug | Cell line | PAR | SOR/PAZ/ERL | |
| Sorafenib | 786-O | 2.7 | 3.2 | 1.2 * |
| HT-29 | 2.0 | 2.5 | 1.2 * | |
| Pazopanib | 786-O | 6.5 | >20 | >3.1 a |
| HT-29 | 0.80 | >20 | >25 a | |
| Erlotinib | 786-O | 4.4 | >20 | >4.5 a |
| HT-29 | 6.3 | >20 | >3.2 a | |
IC50 values of 786-O and HT-29 parental (PAR) and sorafenib (SOR), pazopanib (PAZ) or erlotinib (ERL) selected cell lines determined by MTT proliferation assays. IC50 values are shown as means. Resistance factors are calculated by dividing the IC50 value of the inhibitor selected cell line by the IC50 value of the parental cell line, and is denoted ‘resistant’ when >2.5
*, p value < 0.05; a, p value is not available because IC50 was not reached