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Forest plot of the serum HBeAg loss of combination therapy group vs. nucleoside analogues monotherapy group. Eleven trials reported the serum HBeAg loss rate of chronic hepatitis B patients. A higher potent of HBeAg loss was shown in combination group than in monotherapy group. The highest was combination group vs. Adv group (RR = 2.87, 95% CI = 1.73–4.77, p < 0.001). Total risk ratio was 1.73 (95% CI = 1.32–2.26, p < 0.001).
