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. 2015 Aug 21;12(8):10039–10055. doi: 10.3390/ijerph120810039

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Forest plot of the serum HBV-DNA undetectable rate of combination therapy group vs. nucleoside analogues monotherapy (Lam/ETV/Adv) group. The highest serum HBV-DNA undetectable rate was obtained in the combination therapy group compared with Lam. The risk ratio was 1.87 (95% CI = 1.38–2.54, p < 0.001). The higher serum HBV-DNA undetectable rate was obtained in the combination therapy group compared with Adv. The risk ratio was 1.75 (95% CI = 1.32–2.33, p < 0.001). A significant difference was found between patients in the combination group and ETV group. The risk ratio was 1.64 (95% CI = 1.34–2.01, p < 0.001).