Table 3.
Effect of selected SNPs on various anthropometric and biochemical parameters in the study subjects.
| Parameter | rs9939609 | rs8050136 | rs1121980 | rs9926289 | ||||
|---|---|---|---|---|---|---|---|---|
| Weight | TT TA AA |
73.91 ± 20.90 74.02 ± 20.79 81.74 ± 20.66 |
CC CA AA |
71.39 ± 20.32 76.68 ± 21.25 75.55 ± 20.70 |
GG GA AA |
71.95 ± 20.93 75.39 ± 20.41 84.31 ± 20.54 |
GG GA AA |
71.85 ± 20.33 76.52 ± 21.84 80.20 ± 17.92 |
|
| ||||||||
|
β per risk allele p value |
0.079 0.084 |
0.081 0.075 |
0.041 0.102 |
0.133 0.004∗ |
||||
|
| ||||||||
| BMI | TT TA AA |
27.38 ± 6.36 29.01 ± 6.48 30.39 ± 5.77 |
CC CA AA |
28.71 ± 6.31 29.76 ± 6.48 30.45 ± 6.15 |
GG GA AA |
28.74 ± 6.27 29.58 ± 6.34 31.15 ± 6.58 |
GG GA AA |
27.83 ± 5.56 30.10 ± 6.54 33.57 ± 6.90 |
|
| ||||||||
|
β per risk allele p value |
0.126 0.010∗ |
0.151 0.001∗ |
0.188 0.004∗ |
0.272 0.001∗ |
||||
|
| ||||||||
| WC | TT TA AA |
86.07 ± 12.42 87.09 ± 11.73 88.00 ± 12.79 |
CC CA AA |
85.79 ± 11.20 87.22 ± 12.15 85.58 ± 13.50 |
GG GA AA |
82.94 ± 11.85 84.70 ± 12.40 87.12 ± 12.68 |
GG GA AA |
81.70 ± 12.03 86.45 ± 10.91 89.92 ± 16.22 |
|
| ||||||||
|
β per risk allele p value |
0.019 0.011∗ |
0.009 0.101 |
0.102 0.011∗ |
0.131 0.001∗ |
||||
|
| ||||||||
| HC | TT TA AA |
88.14 ± 13.07 87.27 ± 12.17 89.39 ± 12.45 |
CC CA AA |
88.66 ± 12.07 87.37 ± 12.58 88.29 ± 13.62 |
GG GA AA |
87.48 ± 12.36 88.62 ± 12.52 87.05 ± 14.14 |
GG GA AA |
88.54 ± 12.49 87.32 ± 11.79 88.39 ± 15.95 |
|
| ||||||||
|
β per risk allele p value |
0.007 0.919 |
0.114 0.007∗ |
0.008 0.907 |
0.021 0.744 |
||||
|
| ||||||||
| WHR | TT TA AA |
1.00 ± 0.07 1.00 ± 0.08 0.98 ± 0.05 |
CC CA AA |
0.99 ± 0.06 1.00 ± 0.07 1.01 ± 0.08 |
GG GA AA |
1.01 ± 0.08 0.99 ± 0.06 1.01 ± 0.07 |
GG GA AA |
1.01 ± 0.06 0.99 ± 0.07 1.01 ± 0.10 |
|
| ||||||||
|
β per risk allele p value |
0.059 0.362 |
0.063 0.33 |
0.058 0.37 |
0.02 0.761 |
||||
|
| ||||||||
| Total Cholesterol (mmol/L) | TT TA AA |
4.99 ± 1.08 5.09 ± 1.26 5.49 ± 1.09 |
CC CA AA |
4.90 ± 1.05 5.15 ± 1.19 5.18 ± 1.22 |
GG GA AA |
5.01 ± 1.16 5.10 ± 1.18 5.19 ± 1.01 |
GG GA AA |
5.05 ± 1.26 5.04 ± 1.03 5.31 ± 1.09 |
|
| ||||||||
|
β per risk allele p value |
0.116 0.059 |
0.99 0.033 |
0.137 0.006∗ |
0.05 0.28 |
||||
|
| ||||||||
| Triglycerides (mmol/L) | TT TA AA |
2.30 ± 0.75 2.37 ± 0.94 2.63 ± 0.81 |
CC CA AA |
2.36 ± 0.84 2.32 ± 0.76 2.39 ± 0.97 |
GG GA AA |
2.31 ± 0.78 2.40 ± 0.90 2.32 ± 0.76 |
GG GA AA |
2.30 ± 0.80 2.43 ± 0.91 2.28 ± 0.67 |
|
| ||||||||
|
β per risk allele p value |
0.099 0.031 |
0.011 0.809 |
0.125 0.009∗ |
0.033 0.472 |
||||
|
| ||||||||
| HDL-c (mmol/L) | TT TA AA |
1.44 ± 0.45 1.43 ± 0.50 1.29 ± 0.29 |
CC CA AA |
1.50 ± 0.48 1.39 ± 0.45 1.36 ± 0.43 |
GG GA AA |
1.49 ± 0.47 1.40 ± 0.46 1.22 ± 0.32 |
GG GA AA |
1.47 ± 0.49 1.39 ± 0.43 1.30 ± 0.38 |
|
| ||||||||
|
β per risk allele p value |
−0.079 0.083 |
−0.013 0.111 |
−0.015 0.102 |
−0.116 0.011∗ |
||||
|
| ||||||||
| LDL-c (mmol/L) | TT TA AA |
2.56 ± 0.74 2.67 ± 0.74 2.76 ± 0.70 |
CC CA AA |
2.48 ± 0.78 2.70 ± 0.71 2.67 ± 0.69 |
GG GA AA |
2.61 ± 0.73 2.60 ± 0.77 2.75 ± 0.63 |
GG GA AA |
2.54 ± 0.71 2.65 ± 0.77 2.84 ± 0.67 |
|
| ||||||||
|
β per risk allele p value |
0.098 0.034 |
0.009 0.112 |
0.019 0.677 |
0.122 0.008∗ |
||||
|
| ||||||||
| FPG (mg/dL) | 101.91 ± 13.52 103.21 ± 17.65 107.92 ± 16.54 |
98.45 ± 11.01 99.17 ± 14.75 99.07 ± 13.04 |
100.01 ± 10.52 99.24 ± 17.05 101.92 ± 13.14 |
102.41 ± 12.02 101.27 ± 16.25 102.12 ± 11.51 |
||||
|
| ||||||||
|
β per risk allele p value |
0.198 0.006∗ |
0.019 0.112 |
0.019 0.277 |
0.002 0.208 |
||||
Legend: Values are indicated as mean ± SD. BMI: body mass index, WC: waist circumference, HC: hip circumference, WHR: waist to hip ratio, FPG: fasting plasma glucose, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol. Analysis was done for cases and controls combined.
∗indicates a significant association.