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. 2015 Sep;146(3):245–254. doi: 10.1085/jgp.201511375

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© 2015 Tong et al.

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Figure 5. — Connexin hemichannels are permeable to cytosolic reductants. (A; left) Scheme of TSF method. (Right) Chemical structure of 3-PA and endogenous cellular reductants. (B) Percentage of liposomes permeable to cytosolic reducing agents for liposomes containing either homomeric or heteromeric hemichannels formed by Cx32, Cx26, and Cx32/26. Orange bars, GSH; blue bars, NADH; green bars, NADPH. Homomeric and heteromeric hemichannels were fully permeable through all tested reducers. 3-PA (black bars), a trisaccharide derivative known to be permeable through Cx32 channels but not Cx26-containing channels, was used as control. Error bars represent the mean ± SEM of at least three independent measurements.