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. 2015 Sep;146(3):205–219. doi: 10.1085/jgp.201511383

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© 2015 López Soto et al.

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Figure 6. — GHSR1a activity inhibits native Ca_V2 currents from rat hypothalamic neurons. (A) Representative and averaged I_Ba from nontransfected (nt) and GFP-, GHSR1a-YFP–, and GHSR1a-A204E-YFP–transfected neurons. (B) Normalized I_Ba traces before (control) and after (+ghrelin) 500-nM ghrelin application, and averaged percentage of I_Ba inhibition by ghrelin in each condition. (C) I_Ba time courses of application of 1 µM ω-conotoxin-GVIA (conoTx) and 0.2 µM ω-agatoxin-IVA (agaTx) with or without previous 500-nM ghrelin application from GFP-, GHSR1a-, and GHSR1a-A204E–transfected neurons (left). Averaged percentage of I_Ba sensitive to agaTx and conoTx from nontransfected (nt), GFP-, GHSR1a-, and GHSR1a-A204E–transfected neurons, with (+ghrelin) or without 500-nM ghrelin application (right). (D) Representative and averaged I_Na from nontransfected (nt) and GFP-, GHSR1a-, and GHSR1a-A204E–transfected neurons. ANOVA with Dunnett’s post-test (A–D). *, P < 0.05. Error bars represent mean ± SE.