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Delivery of 2RJ hydrogel decreases fibrosis. (A) Quantification of % fibrosis in rat hearts on day 21 shows a significant increase in fibrosis following 30 min of IR (black bar). Administration of 2RJ hydrogel attenuated this increase; ***p<0.001 versus sham, *p<0.05 versus IR, n≥5 per group. One-way ANOVA followed by Tukey's post-test. (B) Representative images of heart sections stained with picrosirius red and stitched together. IR, ischemia–reperfusion.
