Table 2.
Comparison of Metabolic Outcomes at Baseline, 6 Months, and 12 Months in Those Enrolled Close to Diagnosis
| At enrollment | 6 months | 12 months | |||||||
|---|---|---|---|---|---|---|---|---|---|
| DAISY (n=9) | Community (n=9) | P value | DAISY (n=9) | Community (n=9) | P value | DAISY (n=9) | Community (n=9) | P value | |
| BMI z-score | 0.2±0.7 | 0.1±1.4 | 0.83 | 0.1±0.7 | 0.3±1.0 | 0.65 | 0.4±0.8 | 0.4±0.7 | 0.92 |
| HbA1c (%) | 6.5±1.4 | 9.2±2.9 | 0.0007 | 6.5±1 | 7.8±2.3 | 0.075 | 7.9±0.7 | 8.3±1.5 | 0.56 |
| Glucose tests/day | 3.2±0.9 | 5.2±1.1 | 0.01 | 3.6±1.8 | 4.6±1.0 | 0.046 | 4.9±2.2 | 4.2±1.2 | 0.29 |
| Insulin dose (units/kg/day) | 0.2±0.2 | 0.5±0.3 | 0.007 | 0.3±0.2 | 0.6±0.2 | 0.004 | 0.6±0.3 | 0.8±0.2 | 0.13 |
| IDAA1Ca | 7.4±2.1 | 11.2±3.5 | 0.0003 | 7.6±1.7 | 10.2±2.8 | 0.009 | 10.4±1.5 | 11.3±1.6 | 0.25 |
| C-peptide (ng/mL) | |||||||||
| Fasting | 1.4±1.1 | 1.2±0.5 | 0.32 | 1.0±0.7 | 1.0±0.4 | 0.79 | 1.2±1.1 | 0.8±0.5 | 0.16 |
| 60-min | 2.7±1.3 | 1.7±0.5 | 0.02 | 1.3±0.8 | 1.2±0.4 | 0.78 | 1.8±1.6 | 1.2±0.6 | 0.12 |
Data are mean±SD values unless specified otherwise. P values are derived from mixed-model analysis.
a
Insulin dose-adjusted hemoglobin A1c (IDAA1C), calculated as hemoglobin A1c (HbA1c) (in %)+(4×insulin dose [in units/kg/day]).
BMI, body mass index; DAISY, Diabetes Autoimmunity Study in the Young.