FIG. 4.

E7BMP2pep stimulates new bone formation within subcutaneous graft sites. (A) The total area of new bone formation within grafts harvested from subcutaneous pouches was calculated from H&E-stained sections using Nikon NIS Elements. To compensate for any potential variation in the amount of ABB graft implanted, or differences in ABB surface area, the area of ABB particulate in each section was also measured, and the ratio of new bone to ABB graft was calculated. (B) The average size of the islets of new bone was measured. All measurements were conducted under blinded conditions. For (A, B), values represent means and standard error of the means (n = 8 samples per group). * denotes significant difference relative to uncoated sample (p < 0.05). Color images available online at www.liebertpub.com/tea