Comparison of the effect of three different doses of Radiprodil (1, 2 or 3 mg/kg) given in combination with a fixed dose of Tozadenant (30 mg/kg). For comparison, a dose of L-Dopa 14 mg/kg plus benserazide 3.5 mg/kg and a dose of L-Dopa 25 mg/kg (without benserazide) were also tested. Ipsi turns: RAD3/TOZ is significantly higher than RAD3 (*, p<0.05). VEH significantly lower than TOZ, RAD2 and RAD3 (**, p<0.01); L-Dopa 25 mg/kg is significantly higher than L-Dopa/Benserazide (##, p<0.01). Contra turns: RAD3/TOZ is significantly higher than TOZ (*, p<0.05) and RAD3 (***,p<0.001). VEH is significantly lower than TOZ, RAD2 and RAD3 (**, p<0.01). L-Dopa/benzerazide is significantly higher than L-Dopa 25 mg/kg (###, p<0.001).