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. 2015 Aug 31;10(8):e0135949. doi: 10.1371/journal.pone.0135949

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© 2015 Michel et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Comparison of the effect of three different doses of Radiprodil (1, 2 or 3 mg/kg) given in combination with a fixed dose of Tozadenant (30 mg/kg). For comparison, a dose of L-Dopa 14 mg/kg plus benserazide 3.5 mg/kg and a dose of L-Dopa 25 mg/kg (without benserazide) were also tested. Ipsi turns: RAD3/TOZ is significantly higher than RAD3 (*, p<0.05). VEH significantly lower than TOZ, RAD2 and RAD3 (**, p<0.01); L-Dopa 25 mg/kg is significantly higher than L-Dopa/Benserazide (^##, p<0.01). Contra turns: RAD3/TOZ is significantly higher than TOZ (*, p<0.05) and RAD3 (***,p<0.001). VEH is significantly lower than TOZ, RAD2 and RAD3 (**, p<0.01). L-Dopa/benzerazide is significantly higher than L-Dopa 25 mg/kg (^###, p<0.001).