Figure 2.

Overexpression of miR-497 repressed MDA-MB-231 cell proliferation. A. Relative miR-497 expression of miR-NC group were lower than miR-497 mimics group and higher than miR-497 inhibitor group. B. Upregulation of miR-497 significantly repressed the growth rate of MDA-MB-231 cells, while the inhibitor increased the growth rate (P<0.05). C. Dose-dependent effect of miR-497 mimics on cell growth. The optical density of each well was measured at the indicated time-points with a microplate reader at 490 nm. 100 nM was selected as the optimal concentration for subsequent analyses. The graph represents OD 490 nm ± SD, P<0.05.