. 2015 Jul 1;8(7):7905–7912.

Table 2.

Polymorphisms of NER pathway genes and response to chemotherapy inpatients with osteosarcoma

Gene	Genotypes	MAF		Good responder	%	Non-responder	%	Adjusted OR (95% CI)¹	P values

		In database	Patients
ERCC1 rs11615	CC	0.243	0.235	81	75.70	35	53.85	1.0	-
	CT			16	14.95	15	23.08	0.46 (0.19-1.13)	0.06
	TT			10	9.35	15	23.08	0.27 (0.10-0.71)	< 0.05
ERCC1 rs2298881	AA	0.444	0.378	50	46.73	16	24.62	1.0	-
	AC			48	44.86	34	52.31	0.45 (0.21-0.97)	< 0.05
	CC			9	8.41	15	23.08	0.19 (0.06-0.58)	< 0.05
ERCC2 rs13181	AA	0.095	0.116	92	85.98	51	78.46	1.0	-
	AC			10	9.35	8	12.31	0.69 (0.23-2.16)	0.47
	CC			5	4.67	6	9.23	0.46 (0.11-1.93)	0.21
ERCC2 rs1799793	GG	0.1945	0.209	79	73.83	42	64.62	1.0	-
	GA			17	15.89	13	20.00	0.70 (0.29-1.72)	0.38
	AA			11	10.28	10	15.38	0.58 (0.21-1.68)	0.26
ERCC4 rs1800067	GG	0.0286	0.378	103	96.26	59	90.77	1.0	-
	GA			3	2.80	4	6.15	0.43 (0.06-2.65)	0.27
	AA			1	0.93	2	3.08	0.29 (0.005-5.65)	0.28
ERCC5 rs1047768	TT	0.4930	0.410	44	41.12	21	32.31	1.0	-
	TC			43	40.19	30	46.15	0.68 (0.32-1.45)	0.29
	CC			19	18.69	15	23.08	0.60 (0.24-1.56)	0.25
XPA rs1800975	GG	0.3536	0.363	49	45.79	22	33.85		-
	GA			45	42.06	32	49.23	0.63 (0.30-1.31)	0.18
	AA			13	12.15	11	16.92	0.53 (0.19-1.54)	0.19
XPC rs2228000	CC	0.325	0.323	53	49.53	28	43.08	1.0	-
	CT			42	39.25	29	44.62	0.77 (0.38-1.56)	0.43
	TT			12	11.21	8	12.31	0.79 (0.26-2.52)	0.65
XPC rs2228001	AA	0.372	0.375	47	43.93	20	30.77	1.0	-
	AC			46	42.99	35	53.85	0.56 (0.27-1.17)	0.09
	CC			14	13.08	10	15.38	0.60 (0.21-1.78)	0.29

Adjusted for age, gender, tumor stage and histological type, tumor location and metastasis.