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Effect of honokiol on pro-inflammatory cytokines production in PBMCs. PBMCs were treated with honokiol (0, 5, 10 or 20 μM) for 48 h, the levels of TNF-α (A), IL-1β (B), GM-CSF (C) and IL-8 (D) were determined by ELISA assay. Values are expressed as mean ± SD, n = 5 in each group. *P < 0.05, **P < 0.01, ***P < 0.001 versus control group.
