Table 1.
Clinicopathological parameter, CD3+, CD8+ and FOXP3+ Treg expression in stage II CRC
| CD3+ | CD8+ | FOXP3+ | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| low | high | p-value | low | high | p-value | low | high | p-value | |
| Frequency n (%) | |||||||||
| Gender | .0749 | .7413 | .3194 | ||||||
| Female | 338 (49.1) | 76 (57.6) | 377 (50.7) | 37 (48.7) | 394 (50.1) | 20 (58.8) | |||
| Male | 350 (50.9) | 56 (42.4) | 367 (49.3) | 39 (51.3) | 392 (49.9) | 14 (41.2) | |||
| Age | .0841 | .6181 | .5138 | ||||||
| ≤ 49 | 31 (4.5) | 8 (6.0) | 34 (4.6) | 5 (6.6) | 37 (4.7) | 2 (5.9) | |||
| 50-75 | 402 (58.4) | 88 (66.7) | 443 (59.5) | 47 (61.8) | 467 (59.4) | 23 (67.6) | |||
| ≥ 76 | 255 (37.1) | 36 (27.3) | 267 (35.9) | 24 (31.6) | 282 (35.9) | 9 (26.5) | |||
| Localisation | .0015 | .0034 | .6396 | ||||||
| Right colon | 169 (32.6) | 42 (35.9) | 187 (31.5) | 24 (55.8) | 202 (33.5) | 9 (27.3) | |||
| Left colon | 149 (28.7) | 16 (13.7) | 160 (27.0) | 5 (11.6) | 157 (26.0) | 8 (24.2) | |||
| Rectum | 201 (38.7) | 59 (50.4) | 246 (41.5) | 14 (32.6) | 244 (40.5) | 16 (48.5) | |||
| Grade | .5725 | .8357 | .9407 | ||||||
| G1 | 15 (2.2) | 2 (1.5) | 16 (2.1) | 1 (1.3) | 16 (2.0) | 1 (2.9) | |||
| G2 | 653 (94.9) | 124 (93.9) | 704 94.6) | 73 (96.0) | 745 (94.8) | 32 (94.2) | |||
| G3 | 20 (2.9) | 6 (4.6) | 24 (3.2) | 2 (2.6) | 25 (3.2) | 1 (2.9) | |||
| Stage | .0569 | .0349 | .0549 | ||||||
| pT1 | 48 (7.0) | 15 (11.4) | 56 (7.5) | 7 (9.2) | 59 (7.5) | 4 (11.8) | |||
| pT2 | 157 (22.8) | 39 (29.5) | 169 (22.7) | 27 (35.5) | 186 (23.7) | 10 (29.4) | |||
| pT3 | 414 (60.2) | 70 (53.0) | 445 (59.8) | 39 (51.3) | 464 (59.0) | 20 (58.8) | |||
| pT4 | 69 (10.0) | 8 (6.1) | 74 (10.0) | 3 (4.0) | 77 (9.8) | 0 (0.0) | |||
| Infiltration margin | .3739 | .7947 | .5133 | ||||||
| Pushing type | 192 | 45 | 227 (58.7) | 10 (55.6) | 230 (58.8) | 7 (50.0) | |||
| Infiltrative type | 130 | 38 | 160 (41.3) | 8 (44.4) | 161 (41.2) | 7 (50.0) | |||
| Histology type | .3311 | .3954 | .1693 | ||||||
| Non-mucinous | 668 (97.1) | 130 (98.5) | 723 (97.2) | 75 (98.7) | 764 (97.2) | 34 (100) | |||
| Mucinous | 20 (2.9) | 2 (1.5) | 21 (2.8) | 1 (1.3) | 22 (2.8) | 0 (0.0) | |||
| Peritumoral lymphocyts | .0134 | < .0001 | .2461 | ||||||
| Absent | 240 (74.3) | 50 (60.2) | 285 (73.4) | 5 (27.8) | 282 (71.9) | 8 (57.1) | |||
| Present | 83 (25.7) | 33 (39.8) | 103 (26.6) | 13 (72.2) | 110 (28.1) | 6 (42.9) | |||
| Lymphovascular invasion | .7613 | .3545 | .3976 | ||||||
| Absent | 276 (85.4) | 72 (86.7) | 334 (86.1) | 14 (77.8) | 335 (85.5) | 13 (92.9) | |||
| Present | 47 (14.6) | 11 (13.2) | 54 (13.9) | 4 (22.2) | 57 (14.5) | 1 (7.1) | |||
T-cell densities were grouped in relation to the count distribution quantities according to the median into “low” (n < median) and “high” (n ≥ median). Abbreviations: CRC, colorectal cancer.