Table 3.

Relationship between E6 variants and HPV16 persistent infection

Nucleotide sequence variation	Amino acide variation	Infection		P
		Transient (n=189)	Persistent (n=103)
A131C	R10R	10 (5.29)	17 (16.50)	ˉ
G176A	D25N	6 (3.17)	8 (7.77)	0.091
T178G	D25E	139 (73.54)	60 (58.25)	0.007*
C335T	H78Y	3 (1.59)	5 (4.85)	0.135
T350G	L83V	4 (2.15)	26 (25.24)	<0.001*
A442C	E113D	4 (2.15)	26 (25.24)	<0.001*

Fisher exact test.

^*p<0.05, E6 variants associate with HPV16 persistent infection.