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. 2015 Aug 31;210(5):801–816. doi: 10.1083/jcb.201501076

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© 2015 Hunter et al.

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Figure 6. — Calcium is required for E-cadherin redistribution at the wound margin, purse string formation, and rapid wound repair. (A, B, E, and F) Epidermal cells in embryos expressing endo–E-cadherin:GFP (A and B) or mCherry:moesin (E and F), injected with water (A and E) or BAPTA (B and F) before wounding. Bars, 5 µm. (C and G) Wound area over time for water-injected (blue; n = 8 in C and n = 7 in G) and BAPTA-injected (red; n = 10 in C and n = 7 in G) embryos. (D) Wound closure rate for the fast phase of tissue repair. (H) Maximum fold enrichment of mCherry:moesin at the wound margin. (I and J) Kymographs showing E-cadherin:GFP redistribution along cell interfaces at the wound margin. Anterior left, dorsal up. Bars, 30 s. (K) Percentage of decrease in E-cadherin:GFP fluorescence along wound margin interfaces 15 min after wounding in water-injected (n = 22 interfaces) and BAPTA-injected (n = 21 interfaces) embryos. (A–D) Time after wounding is shown. Red lines indicate wound sites. Yellow dotted lines outline the wounds. Anterior left, dorsal up. Error bars, SEM; *, P < 0.05; **, P < 0.01.