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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Glia. 2015 Jul 17;63(12):2285–2297. doi: 10.1002/glia.22893

Figure 7. Reduced KCNJ10 and SLC1A2 mRNA expression correlates with GFAP accumulation in hGFAPTG mice.

Figure 7

A. Western blot analysis of WT spinal cord demonstrates increased Kir4.1, GLT-1 and GFAP proteins during the first two postnatal weeks. B. Quantitative PCR demonstrates KCNJ10 mRNA increases during the first two postnatal weeks. KCNJ10 mRNA does not increase to the same level in hGFAPTG mice. C. Quantitative PCR demonstrates SLC1A2 mRNA increases during the first two postnatal weeks. SLC1A2 mRNA does not increase to the same level in hGFAPTG mice. D. Quantitative PCR demonstrates endogenous mouse GFAP mRNA increases during the first two postnatal weeks. At PND14 endogenous GFAP mRNA in hGFAPTG mice is elevated relative to WT mice. E. Human GFAP transcript also increases in hGFAPTG mice. F. Western blot demonstrates GFAP protein accumulation is evident at PND7 in hGFAPTG mice. *=p<0.05, **=p<0.01