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Structural comparison of hDSPRY (green) with the SPRY domain of Ash2L (red; PDB entry 3toj; Chen et al., 2012 ▸) using the DALI server (Holm & Rosenström, 2010 ▸). Regions that show most significant structural differences are indicated by intense colour shading and are marked by grey circles. The 44-residue loop of Ash2L that is not resolved in the crystal structures is marked with a red circle. Loop D is highlighted in purple.
