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Tyrosine kinase inhibition by nintedanib in a cellular BA/F3 assay
| Assay | IC50 (nM) |
|---|---|
| FGFR1 | 300–1,000 |
| FGFR2 | 257 |
| FGFR3 | 300–1,000 |
| FGFR4 | 300–1,000 |
| PDGFRα | 41 |
| PDGFRβ | 58 |
| VEGFR1 | 300–1,000 |
| VEGFR2 | 46 |
| VEGFR3 | 33 |
| LCK | 22 |
| LYN | 300–1,000 |
| SRC | 811 |
| FLT-3 | 17 |
Abbreviations: FGFR, fibroblast growth factor receptor; PDGFR, platelet-derived growth factor receptor; VEGFR, vascular endothelial growth factor receptor.
