Table 1.

Strategies being considered to provoke T cell-based inflammation in the tumor microenvironment.

Goal	Candidate intervention
1. Promote innate immunity/type I IFNs	Intratumoral STING agonists TLR agonists Local radiation Targeted IFN-α/IFN-β
2. Induce tertiary lymphoid structures	Intratumoral LIGHT
3. Modulate stroma	Anti-CD40 EtB receptor inhibitors
4. Inhibit immunosuppressive oncogene pathways	β-catenin inhibitors Stat3 inhibitors
5. Modulate microbiota	Probiotics