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. 2015 Sep 1;6:870. doi: 10.3389/fmicb.2015.00870

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Copyright © 2015 Ramesha, Venkataramana, Nirmaladevi, Gupta, Chandranayaka and Srinivas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological observations of spleen upon treatment with different concentrations of oosporein. Histopathology of spleen stained with hematoxylin-eosin-methylene blue. (A) Control spleen showed no histopathological damage, whereas oosporein exposed spleen showed clear evidence of histopathological damage with splenic granulomas, macrophage infiltration and splenomegaly as shown as arrow marks. Damage was graded as (B) mild, (C) mild, (D) moderate, (E) moderate, and (F) severe extreme.