Table 2. Regions showing FA reduction in patients with psychosis.
Index | A | B | C | D | E | |
---|---|---|---|---|---|---|
MNI co-ordinates of COG in x, y, z | −7, 14, 21 | −27, −65, 17 | 17, −26, 36 | 23, −63, 29 | −17, −39, 39 | |
WM tract labels a | Body of the Corpus Callosum | Left Posterior Thalamic (optic) Radiation, Forceps Major | Body of the Corpus Callosum | Right Inferior Fronto-occipital Fasciculus | Left Cingulate Gyrus Corona Radiata | |
Cluster Extent | 3212 | 1585 | 1428 | 822 | 110 | |
FA | Mean (SD) CTRLS | 0.697 (0.025) | 0.649 (0.025) | 0.572 (0.032) | 0.574 (0.025) | 0.506 (0.038) |
Mean (SD) SCZ | 0.682 (0.025) | 0.624 (0.025) | 0.555 (0.032) | 0.548 (0.025) | 0.479 (0.038) | |
Mean (SD) BPP | 0.679 (0.028) | 0.627 (0.028) | 0.548 (0.028) | 0.542 (0.023) | 0.481 (0.038) | |
Diagnosis | F = 6.903 * | F = 15.970 * | F = 5.614 * | F = 10.930 * | F = 4.649 * | |
AD | Mean (SD) CTRLS | 0.150 (0.006) | 0.143 (0.006) | 0.128 (0.006) | 0.129 (0.006) | 0.117 (0.006) |
Mean (SD) SCZ | 0.151 (0.006) | 0.141 (0.006) | 0.129 (0.006) | 0.126 (0.006) | 0.118 (0.006) | |
Mean (SD) BPP | 0.151 (0.004) | 0.141 (0.004) | 0.129 (0.004) | 0.126 (0.004) | 0.118 (0.004) | |
Diagnosis | F = 0.231 | F = 1.800 | F = 0.773 | F = 2.900 | F = 0.474 | |
RD | Mean (SD) CTRLS | 0.380 (0.006) | 0.420 (0.006) | 0.460 (0.006) | 0.460 (0.006) | 0.500 (0.006) |
Mean (SD) SCZ | 0.410 (0.006) | 0.460 (0.006) | 0.500 (0.006) | 0.500 (0.006) | 0.540 (0.006) | |
Mean (SD) BPP | 0.400 (0.004) | 0.440 (0.004) | 0.490 (0.004) | 0.490 (0.004) | 0.530 (0.004) | |
Diagnosis | F = 6.070 * | F = 6.887 * | F = 4.667 * | F = 4.373 * | F = 3.165 * | |
MoA | Mean (SD) CTRLS | 0.885 (0.032) | 0.728 (0.051) | 0.685 (0.064) | 0.594 (0.077) | 0.559 (0.115) |
Mean (SD) SCZ | 0.870 (0.031) | 0.685 (0.050) | 0.648 (0.063) | 0.540 (0.076) | 0.495 (0.113) | |
Mean (SD) BPP | 0.873 (0.032) | 0.708 (0.051) | 0.646 (0.061) | 0.539 (0.075) | 0.530 (0.117) | |
Diagnosis | F = 3.235 * | F = 6.691 * | F = 4.644 * | F = 7.050 * | F = 2.277 |
All clusters survived FWE corrected p value <0.05.
White matter labels are provided in accordance with JHU White Matter Tractography Atlas and the ICBM DTI-81 White Matter Labels Atlas (Mori et al. 2005). Only tracts with >5% probability are included in the labels.
Denotes p<0.05 for F tests.