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Association between tumor budding and histologic subtype. High-grade tumor budding was most frequently identified in solid-predominant tumors (53%), followed by micropapillary-predominant (42%), and acinar-predominant (34%) tumors. Rate of high-grade tumor budding was significantly higher in solid-predominant tumors than in tumors of other subtypes (P < .001). AIS = adenocarcinoma in situ; MIA = minimally invasive adenocarcinoma.
