TABLE 3 ] .

Multivariate Analysis for CIR

Variables	Hazard Ratio	95% CI	P Value
Sex
Male vs female	1.48	1.06-2.06	.022
Surgery
Limited resection vs lobectomy	3.00	2.11-4.27	< .001
Pathologic stage
IB vs IA	1.80	1.27-2.55	.001
Architectural grade
Intermediate vs high	0.50	0.35-0.70	< .001
Low vs high	0.23	0.08-0.64	.005
Lymphatic invasion
Positive vs negative	1.34	0.92-1.95	.13
Necrosis
Positive vs negative	1.13	1.04-1.22	.004
Mitotic count
Intermediate vs low	1.16	0.70-1.92	.57
High vs low	1.44	0.92-2.25	.11
Tumor budding
High vs low	1.61	1.13-2.29	.008

See Table 1 legend for expansion of abbreviation.