TABLE 4 ] .
Association Between Tumor Budding and Immune Markers
| Immune Markers | Tumor Budding, No. (%) | P Value | |
| Low-Grade | High-Grade | ||
| Tumoral CD3+ lymphocyte | .66 | ||
| Low | 352 (70) | 154 (30) | |
| High | 274 (68) | 129 (32) | |
| Stromal CD3+ lymphocyte | < .001a | ||
| Low | 448 (73) | 167(27) | |
| High | 170 (59) | 118 (41) | |
| Tumoral FoxP3+ lymphocyte | .37 | ||
| Low | 309 (71) | 128 (29) | |
| High | 315 (68) | 150 (32) | |
| Stromal FoxP3+ lymphocyte | < .001a | ||
| Low | 426 (74) | 153 (26) | |
| High | 185 (59) | 127 (41) | |
| Tumoral FoxP3/CD3 risk index | .79 | ||
| Low | 362 (69) | 159 (31) | |
| High | 258 (68) | 119 (32) | |
| Stromal FoxP3/CD3 risk index | < .001a | ||
| Low | 459 (71) | 183 (29) | |
| High | 136 (59) | 96 (41) | |
| Tumoral CD68 macrophage | < .001a | ||
| Low | 194 (81) | 46 (19) | |
| High | 388 (64) | 222 (36) | |
| Stromal CD68 macrophage | < .001a | ||
| Low | 231 (80) | 58 (20) | |
| High | 305 (61) | 191 (39) | |
| Tumoral IL-7R | < .001a | ||
| Low | 411 (77) | 126 (23) | |
| High | 215 (58) | 157 (42) | |
| Tumoral IL-12Rβ2 | .99 | ||
| Low | 475 (69) | 214 (31) | |
| High | 151 (69) | 68 (31) | |
FoxP3 = forkhead box P3; IL-7R = IL-7 receptor; IL-12Rβ2 = IL-12 receptor β2.
a
Significant P values.