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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Cell Res. 2015 May 7;335(1):115–122. doi: 10.1016/j.yexcr.2015.04.019

Figure 5. Phosphorylation of specific serines on the PDPN intracellular domain affect cell migration.

Figure 5

PKA can phosphorylate serines S167 or S171 on the intracellular domain of PDPN, whereas CDK5 preferentially phosphorylates S171. However, phosphorylation of both intracellular serines on PDPN is required to inhibit PDPN mediated cell migration. Thus, PKA and CDK5 may phosphorylate PDPN S167 and S171, respectively, in order to decrease cell motility.