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Metabolic stability parameters of praziquantel and its analogs as determined from incubation with HLM
| t1/2 (min) | CLint (μl/min/mg microsomal protein) | Hepatic CLint (ml/min) | ER | Hepatic CL (ml/min) | |
|---|---|---|---|---|---|
| Praziquantel | 33.5 | 41.4 | 2022.0 | 0.59 | 827.2 |
| PZ02 | 60.8 | 22.8 | 1113.6 | 0.44 | 620.2 |
| PZ07 | 63.0 | 22.0 | 1074.5 | 0.43 | 607.9 |
| PZ10 | 85.6 | 16.2 | 791.2 | 0.36 | 505.5 |
