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. 2015 Aug 27;10:5447–5457. doi: 10.2147/IJN.S81172

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© 2015 Teng et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Preparation and characterizations of the NPs.

Notes: (A) Particle size and size distribution of siRNA-loaded PEAL NPs. (B) TEM image of siRNA-loaded PEAL NPs. (C) Stability of the NPs in PBS (pH 7.4, 0.01 M). (D) Cumulative released rate of siRNA from nanoparticles. Data are represented as means ± SD, n=3.

Abbreviations: PDI, polydispersity index; siRNA, small interfering RNA; PEAL NPs, mPEG-PLGA-PLL nanoparticles; mPEG-PLGA-PLL, monomethoxy polyethylene glycol–polylactic acid/glycolic acid–poly(L-lysine) triblock copolymer; TEM, transmission electron microscopy; PBS, phosphate buffer saline; h, hours.