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. Author manuscript; available in PMC: 2016 Aug 13.
Published in final edited form as: Cell. 2015 Aug 13;162(4):872–884. doi: 10.1016/j.cell.2015.07.041

Figure 5. Reinitiation most likely occurs at non-AUGs near the main ORF stop codon.

Figure 5

(A) Average fraction of ribosome occupancy was computed for stop codons in 5-nt windows downstream of the main ORF stop codon, and peak enrichment was plotted versus the center of each window. Data for the 0–4 nt window could not be computed due to interfering reads from the pause on the main stop codon of the ORF. (B) Schematics (left) illustrate potential reinitiation mechanisms. Average fraction of ribosome occupancy (right) in a window surrounding 3′UTR stop codons, sorting data by the presence or absence of an upstream, in-frame AUG (top) or main-ORF penultimate codon (bottom) in the 3′UTR.