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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: ACS Chem Neurosci. 2015 Jun 12;6(8):1476–1485. doi: 10.1021/acschemneuro.5b00134

FIGURE 6. Inhibitory effects of compound 13 and CsA on CY and CyPA PPIase activities.

FIGURE 6

(a) Direct inhibition of PPIase activity of CY by compound 13. Compound 13 has an IC50 of ≃4×10−13 M on the catalytic efficiency (kcat/Km) of CY. (b) Inhibitory effects of CsA and compound 13 on the catalytic efficiencies of CyPA and CY of Ranbp2. Data shown represent the mean ± s.d., n =4–6 (b). Legend: V, vehicle; Cmp, compound (small molecule).