Table 1.

Study flow chart

Assessment Cluster	Visit 1 (Screening/Baseline)	Visit 2 (Day of Surgery)	Visit 3 (Postop. Day 1)	Visit 4 (Postop. Day 2)	Visit 5 (Postop. Day 3)	Visit 6 (Day of Discharge)	Visit 7 (6 Months Postop)	Visit 8 (12 Months Postop)
Informed consent	X
Demographics form	X
Patient questionnaires
Brief Pain Inventory (BPI) pain severity and interference	X			X		X	X	X
Pain interference: PROMIS	X					X	X	X
Neuropathic pain: S-LANSS	X						X	X
Anxiety: PROMIS	X						X	X
Depression: PROMIS	X						X	X
Sleep disturbance: PROMIS	X						X	X
Perceived stress: PSS	X							X
Somatization: BSI-S	X							X
Positive affect: PANAS	X						X	X
Catastrophizing: PCS	X						X	X
Neuroticism/emotional stability	X							X
Clinical assessments
Pain at rest: NRS	X		X	X	X
Range of motion	X		X	X	X		X	X
Pain with movement: NRS	X		X	X	X		X	X
Pressure algometry threshold	X		X	X	X
Pain with pressure algometry: NRS	X		X	X	X
Touch threshold: Von Frey hair	X		X	X	X
Muscle strength: hand held dynamometer	X		X	X	X
Situational pain catastrophizing	X		X	X	X
Pain thermal threshold: medoc TSA-II	X			X
Pain with heat: NRS	X			X
Laboratory assessments
DNA testing: blood sampling		X
Cytokine panel: joint fluid (N = 75)		X	X§
Cytokine panel: Urine (N = 75)		X
Medication assessments
Patient-controlled analgesia		X		Xdc
Concomitant medications	X	X	X	X	X		X	X
Femoral and sciatic nerve blocks (start and d’c)		X		Xs	Xf

^§When the drain is removed, the joint fluid will be collected.

^dcPCA (patient-controlled analgesia) discontinued.

^sSciatic block discontinued.

^fFemoral block discontinued.

Abbreviations: BSI-S = brief symptom inventory-somatization scale; NRS = numeric rating scale; PANAS = positive and negative affect scale; PCS = pain catastrophizing scale; PROMIS SF = Patient-Reported Outcomes Management Information System—Short Form; PSS = Perceived Stress Scale (4 item version); S-LANSS = Leeds Assessment of Neuropathic Symptoms and Signs.