Table 2.
Ad-ISF35-transduced cell product
Subject number (initials) | 1 (MP) | 2 (RL) | 3 (RG) | 4 (RT) | 5 (RM) | 6 (JC) | 7 (BF) | 8 (JW) | 9 (LH) |
Intended dose (ISF35-cells) | 1×108 | 1×108 | 1×108 | 3×108 | 3×108 | 3×108 | 1×109 | 1×109 | 1×109 |
Volume infused (ml) | 10 | 10 | 10 | 10 | 10 | 10 | 30 | 30 | 30 |
% ISF35 transduction | 49 | 77 | 52 | 57 | 58 | 40 | 42 | 54 | 41 |
ISF35 MFIR | 2.0 | 6.9 | 2.1 | 2.9 | 2.9 | 1.8 | 3.7 | 2.1 | 2.2 |
%CD95+ in transduced | 83 | 96 | 94 | 97 | 96 | 93 | 90 | 78 | 93 |
CD95 MFIR in transduced | 7.6 | 43.6 | 15.0 | 34.4 | 33.4 | 17.4 | 20.3 | 11.7 | 27.1 |
Free Ad-ISF35 (p/ml) | 8.7×106 | 4.3×106 | 3.0×106 | 5.4×106 | 7.8×106 | 5.3×106 | 4.2×106 | 1.8×107 | 2.8×106 |
Total free Ad-ISF35 infused | 8.7×107 | 4.3×107 | 3.0×107 | 5.4×107 | 7.8×107 | 5.3×107 | 1.3×108 | 5.4×108 | 8.4×107 |
Abbreviations: MFIR, mean fluorescence intensity ratio; p/ml, particles/ml.