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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Bioessays. 2015 Jun 9;37(8):856–861. doi: 10.1002/bies.201500021

Figure 2.

Figure 2

Potential models by which SUUR could inhibit active replication forks. Depicted is a model in which SUUR becomes recruited to replication forks late in S phase. Once at a replication fork, SUUR could prevent the decondensation of highly condensed regions of chromatin (e.g. heterochromatin) through competition with a chromatin remodeling factor. Also, SUUR could directly inhibit a key activity associated with replication fork progression, such as helicase activity. It is important to note that these two models of SUUR function are not mutually exclusive.