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. 2015 Aug 31;10(8):e0136822. doi: 10.1371/journal.pone.0136822

Fig 5. Summary of changes in the methionine cycle, transsulfuration pathway and methyltransferase reactions in advance NAFLD.

Fig 5

HFHC diet for 52 weeks resulted in methionine depletion, excess homocysteine and aberrancy in transmethylation pathway. The decrease in the substrate serine impairs homocysteine remethylation and limits the ability to replete glutathione in the transsulfuration pathway. Legend: cystathionine β-synthase (CBS); dimethylglycine (DMG); γ-glutamylcysteine synthetase (GCS); glutathione (GSH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR); methionine adenosyltransferase (MAT); phosphatidylcholine (PC); phosphatidylethanolamine (PE); protein arginine methytransferas 1 (PRMT1); s-adenosylmethionine (SAM); s-adenosylhomocysteine (SAH); s-adenosylhomocysteine hydrolase (SAHH).