Table 1. Morphological and biochemical profile at 52 weeks of chow and HFHC diet.
| Chow (n = 6) | HFHC (n = 8) | P-value | |
|---|---|---|---|
| Body weight (gram) | 36.7 ± 2.4 | 50.5 ± 3.0 | <0.05 |
| Liver weight (gram) | 1.3 ± 0.1 | 2.4 ± 0.4 | <0.05 |
| Insulin (mU/l) | 48.4 ± 5.1 | 65.5 ± 8.7 | <0.05 |
| HOMA-IR | 43.6 ± 5.8 | 61.78 ± 8.2 | <0.05 |
| AST (unit/L) | 220.8 ± 57.6 | 628.4 ± 83.6 | <0.01 |
| ALT (unit/L) | 58 ± 6.0 | 560.5 ± 127.5 | <0.01 |
| ALP (unit/L) | 40.5 ± 8.9 | 132.0 ± 26.0 | <0.05 |
| GGT (unit/L) | <0.5 | <0.5 | NA |
| Bilirubin (mg/dl) | <0.1 | <0.1 | NA |
| Cholesterol (mg/dl) | 128.8 ± 10.6 | 337.4 ± 40.2 | <0.01 |
| HDL (mg/dl) | 54.3 ± 4.4 | 105.8 ± 6.5 | <0.01 |
| LDL (mg/dl) | 56.0 ± 6.3 | 209.8 ± 33.3 | <0.01 |
| Triglyceride (mg/dl) | 92.7 ± 1.1 | 110.9 ± 2.6 | <0.05 |
Data are represented as mean ± SEM. aspartate aminotransferase, AST; alanine aminotransferase, ALT; alkaline phosphatase, ALP; gamma-glutamyltransferase, GGT; high-density lipoprotein, HDL; high-fat high-calorie, HFHC; homeostasis model assessment of insulin resistance, HOMA-IR; low-density lipoprotein, LDL