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. 2015 Jun 25;106(8):972–981. doi: 10.1111/cas.12700

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Association between mRNA expression of Igf2 and its related genes in CCl₄- and thioacetamide (TAA)-induced tumors. (a) Scatter plot showing a positive correlation between the mRNA expression of Igf2 and H19 in CCl₄-induced tumors (n = 27) and TAA-induced tumors (n = 9). Spearman’s correlation coefficient was used to test the correlation between the expression of the transcripts. (b) Igf2bp3 mRNA expression in tumors with substantial Igf2 mRNA expression (Igf2^high, Igf2/Gapdh ≥0.01; CCl₄-induced tumors, n = 12; TAA-induced tumors, n = 3) and very low or no Igf2 mRNA expression (Igf2^low, Igf2/Gapdh <0.01; CCl₄-induced tumors, n = 19; TAA-induced tumors, n = 6). **P < 0.01; unpaired two-tailed t-test.